Research Articles
Monoubiquitination vs. Polyubiquitination: Decoding Functional Consequences for Targeted Therapies
This article provides a comprehensive analysis of the distinct functional consequences of monoubiquitination and polyubiquitination, two critical protein modifications that govern cellular signaling.
Comparative Analysis of Mass Spectrometry Databases for Ubiquitination Site Identification: Strategies, Tools, and Best Practices
The systematic identification of protein ubiquitination sites via mass spectrometry (MS) is fundamental to understanding cellular signaling, protein degradation, and disease mechanisms.
Decoding Cancer's Ubiquitination Blueprint: From Molecular Mechanisms to Clinical Applications
This comprehensive review synthesizes current knowledge on the systematic alterations in ubiquitination patterns between cancerous and normal tissues.
Decoding the Ubiquitin Code: A Comprehensive Guide to Validating Chain Architecture Using Linkage-Specific DUBs
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to the theory and application of deubiquitinase (DUB)-based analysis for validating ubiquitin chain architecture.
Ubiquitinomics vs Proteomics: The Next Frontier in Cancer Biomarker Discovery
This article provides a comprehensive comparison between ubiquitinomics and proteomics for researchers and drug development professionals engaged in cancer biomarker discovery.
Ubiquitination and Phosphorylation Crosstalk: Integrating Signals for Cellular Control and Therapeutic Innovation
This article provides a comprehensive analysis of the intricate crosstalk between ubiquitination and phosphorylation, two paramount post-translational modifications (PTMs) governing eukaryotic cell signaling.
Ubiquitination-Related Genes as Prognostic Biomarkers in Cancer: From Molecular Mechanisms to Clinical Applications
This comprehensive review explores the rapidly advancing field of ubiquitination-related genes (UbRGs) as prognostic biomarkers in oncology.
Ubiquitin Linkage-Specific Antibodies: A Comprehensive Guide to Sensitivity, Specificity, and Application
This article provides a critical resource for researchers and drug development professionals navigating the complex landscape of ubiquitin linkage-specific antibodies.
Preserving Ubiquitin Chains: A Comprehensive Guide to Preventing Disassembly During Immunoprecipitation
This article provides researchers, scientists, and drug development professionals with a complete methodological framework for preserving labile ubiquitin modifications during immunoprecipitation experiments.
Validating Ubiquitination Sites: A Comprehensive Guide to Mutagenesis and Immunoblotting for Researchers
This article provides a detailed methodological guide for researchers and drug development professionals on validating protein ubiquitination sites through the combined power of site-directed mutagenesis and immunoblotting.